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CBX5 (gene)
Chromobox protein homolog 5 is a protein that in humans is encoded by the ''CBX5'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23468 )〕 It is a highly conserved, non-histone protein part of the heterochromatin family. The protein itself is more commonly called (in humans) HP1α and acts on methylated lysines residues leading to epigenetic repression.〔 == Structure == HP1α is 191 amino acids in length containing 6 exons.〔Lomberk, Gwen, Lori Wallrath, and Raul Urrutia. "The heterochromatin protein 1 family." ''Genome Biol'' 7.7 (2006): 228.〕 As mentioned above, this protein contains two domains, an N-terminal chromodomain (CD) and a C- terminal chromoshadow domain (CSD). The CD binds with histone 3 through a methylated lysine residue at position 9 (H3K9) while the C-terminal CSD homodimerizes and interacts with a variety of other chromatin-associated, non-histone related proteins.〔 Connecting these two domains is the hinge region.
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